Accessing Targeted Nanoparticles to the Brain: The Vascular Route

摘要: The blood-brain barrier (BBB), formed by brain capillary endothelial cells, prevents the entry of several drug molecules to brain, especially molecules hydrophilic in nature. Advanced drug carriers like nanoparticles share potential to allow therapeutic proteins and genetic into central nervous system (CNS). Taking a targeting approach conjugating acting as ligands or monoclonal antibodies with affinity for expressed on luminal side can be designed enable transport brain endothelium, perhaps even through endothelium leading blood transport. Currently, iron-binding protein transferrin raised against transferrin receptor denote most feasible molecule targeting purposes at BBB. This manuscript reviews targetability how nanocarriers may enter transfer endothelium, how likely restraints denoted threedimensional mesh extracellular forming basement membrane challenge possibilities for enabling large BBB encapsulated nanoparticles.