Internalization and Processing of Peptide Hormone Receptors

摘要: There are two major mechanisms of a general nature by which macro-molecules can gain entrance into intact, living cells (Pastan and Willingham, 1981a). One these is generally referred to as fluid-phase endocytosis, nonconcentrative, nonadsorptive mechanism that internalizes anything happens be in the surrounding medium cell. basic organelles pathways recognized for this process. In one these, very small invaginations cell membrane at surface pinch off internalize endocytic vesicles. These vesicles go directly lysosomes, reaching them within minutes, where they fuse dislodge their contents lysosomes. The other process involves fusing large ruffles membrane, thus trapping quite substantial quantities exterior medium. vacuoles or again travel rapidly area lysosomal structures, on impact apper shatter many vesicles, subsequently with