MicroRNA-154: A Novel Candidate for Diagnosis and Therapy of Human Cancers.

摘要: MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded, tiny RNAs with 21-23 nucleotides that regulate several biological functions through binding to target mRNAs and modulating gene expression at post-transcriptional levels. Recent studies have described crucial roles for miRNAs in pathophysiology of numerous human cancers. They can act as an oncogene promote cancer or a tumor suppressor alleviate the disease. Recently discovered microRNA-154 (miR-154) has been proposed be involved multiple physiological pathological processes including cancer. With this aspect, aberrant miR-154 demonstrated variety malignancies, suggesting important role tumorigenesis. To specific, it is considered miRNA exerts its beneficial effects by targeting genes. This review systematically summarizes recent advances done on different cancers discusses potential prognostic, diagnostic therapeutic values.