Properties of biodegradable hydrogels prepared by γ irradiation of microbial poly(ε-lysine) aqueous solutions

摘要: Poly(e-lysine) (PL) hydrogels have been prepared by means of γ irradiation PL produced Streptomyces albulus in aqueous solutions. When the dosage was 70 kGy or more and concentration water 1-7 wt %, transparent (opaque for 1-3 % concentration) could be produced. In case 5 concentration, specific content (wt absorbed water/wt dry hydrogel) hydrogel approximately 160. Specific contents decreased markedly with an increase irradiation. The were increased irradiated solution. This result indicates presence a radical scavenger Swelling equilibria measured solutions various pHs concentrations NaCl, Na 2 SO 4 , CaCl . Under acid conditions, swelled due to ionic repulsion protonated amino groups molecules. degree deswelling electrolyte solution smaller than that other [poly(γ-glutamic acid), poly(acrylic acid) etc.]. addition, enzymatic degradations studied at 40°C pH 7.0 neutral protease [Protease A (Amano)] from Aspergillus oryzae. rate degradation respective much faster simple hydrolytic degradation. γ-irradiation dose during preparation hydrogel. © 1995 John Wiley & sons, Inc.