Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice.
作者： Z. Iqbal , K Dahl , S. Epstein
关键词: Chemistry 、 Parts-per notation 、 Dichloromethane 、 Chromatography 、 Methanol 、 Distilled water 、 Liquid nitrogen 、 Nitrogen dioxide 、 Gas chromatography 、 Environmental chemistry 、 Morpholine
摘要: Groups of three to four mice were gavaged with aqueous solutions 2 milligrams morpholine, after which they exposed nitrogen dioxide in inhalation chambers at concentrations 0.2 50 parts per million for up 4 hours. At sequential intervals during the exposure, frozen and pulverized liquid nitrogen, powder was extracted ice-cold 35 percent methanol dichloromethane; organic-phase concentrates analyzed N-nitrosomorpholine a thermal energy analyzer interfaced gas chromatograph. The yields, ranging about 2.3 micrograms mouse, time-dependent relative duration exposure dose-dependent dioxide; control levels (in that morpholine or distilled water then air instead dioxide) less than 5 nanograms mouse. These preliminary studies demonstrate vivo nitrosating potential oxides.
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