Innovation inspired by nature: Biocompatible self-healing injectable hydrogels based on modified-β-chitin for wound healing.

摘要: Abstract Remarkable properties of hydrogels are compromised by failure to recover from damage, bringing their intended functions an end. To address this, can be functionalized with self-healing property enable them restore themselves after thus, extending lifetime. Herein, were prepared cross-linking acrylamide-modified β-chitin (Am-β-Chn) alginate dialdehyde (ADA) form Schiff base, showing IR characteristic peak at 1650 cm−1, attributed the stretching vibration C N. The dynamic base and H-bond rendered double crosslinked as demonstrated continuous step strain rheology. Characterization revealed excellent biocompatibility, biodegradability, injectability properties. Furthermore, wound healing was investigated in vivo using zebrafish a model system. Indirect application Am-β-Chn/ADA hydrogel remarkably led ~87% compared control which gave ~50%, suggesting that effective accelerating healing. However, clear understanding exact mechanism its remains investigated. best our knowledge, this is first innovation developing novel both accelerated properties, directly marine-food wastes.