Clastogenesis in Vitro Under Extreme Culture Conditions
作者： D. Scott
DOI: 10.1007/978-3-642-75682-5_26
关键词: In vitro 、 Bone marrow 、 Bioassay 、 Clastogen 、 Micronucleus test 、 Molecular biology 、 Chromosome aberration 、 Chemistry 、 In vivo 、 Mitotic index
摘要: Approximately 50% of chemicals that are clastogenic in mammalian cells vitro do not induce chromosome aberrations or micronuclei the bone marrow rodents (Thompson 1986; Ishidate et al. 1988). There many possible reasons for this discrepancy (see Waters 1988) including: 1. The absence detoxification excretion processes vitro; 2. Metabolic unique to bioassay create active clastogens; 3. The insensitivity test; 4. Extreme culture conditions producing clastogenesis could be achieved vivo.
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