Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
作者： Wagdy M. Eldehna , Sara T. Al-Rashood , Tarfah Al-Warhi , Razan O. Eskandrani , Amal Alharbi
DOI: 10.1080/14756366.2020.1862101
关键词: Kinase 、 Benzofuran 、 Cancer research 、 Serine 、 Breast cancer 、 Threonine 、 Oxindole 、 Chemistry 、 In silico 、 Cyclin-dependent kinase 2
摘要: The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were …
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