The flavivirus protease as a target for drug discovery.

摘要: Many flaviviruses are significant human pathogens causing considerable disease burdens, including encephalitis and hemorrhagic fever, in the regions which they endemic. A paucity of treatments for flaviviral infections has driven interest drug development targeting proteins essential to flavivirus replication, such as viral protease. During genome is translated a single polyprotein precursor, must be cleaved into individual by complex protease, NS3, its cofactor, NS2B. Because this cleavage an obligate step life-cycle, protease attractive target antiviral development. In review, we will survey recent studies NS3 active site, well NS2B/NS3 interaction site determined from crystal structures.