Functional Aspects of Proteoglycan Domain Structure

摘要: Proteoglycans, a class of extracellular macromolecules characteristically consisting protein core substituted with one or several glycosaminoglycan chains, have profound influence on the physical properties matrix and pericellular space. Many proteoglycans multidomain structure where distinct biological can be assigned to particular, often well conserved portions core. In present chapter we review functional aspects proteoglycan domain using large aggregating interstitial as an example. These molecules are abundant in many types matrix, but most pronouncedly so cartilage. There they do by formation aggregates hyaluronate fill space between collagen fibers make tissue resilient pressure (for see Heinegard Paulsson, 1984). Interstitial does addition contain two more populations small proteoglycans. At least certain members affinity for fibrils thought regulate fibril (Scott Orford, 1981? Vogel et al,