Anti-Candida properties of urauchimycins from actinobacteria associated with trachymyrmex ants.

摘要: After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency isolation new molecules has decreased. To cope with this concern, studies have focused on exploitation actinobacteria unexplored environments and symbionts plants animals. In study, twenty-four strains isolated workers Trachymyrmex ants were evaluated antifungal activity towards a variety Candida species. Results revealed that seven inhibited tested Streptomyces sp. TD025 presented potent broad spectrum inhibition was selected bioactive molecules. From liquid shake culture bacterium, we rare antimycin urauchimycins A B. For first time, these against medically important Both antimycins showed activity, especially urauchimycin This compound growth all species tested, minimum inhibitory concentration values equivalent to nystatin. Our results concur predictions attine ant-microbe symbiosis may be source metabolites biotechnology medical applications.