Transmission dynamics of re-emerging rabies in domestic dogs of rural China

摘要: Despite ongoing efforts to control transmission, rabies prevention remains a challenge in many developing countries, especially rural areas of China where re-emerging is under-reported due lack sustained animal surveillance. By taking advantage detailed genomic and epidemiological data for the outbreak Yunnan Province, China, collected between 1999 2015, we reconstruct demographic dispersal history domestic dog virus (RABV) as well dynamics dog-to-dog dog-to-human transmission. Phylogeographic analyses reveal lower diffusion coefficient than previously estimated RABV dissemination northern Africa. Furthermore, transmission rates dogs, dogs humans, estimates Finally, show that reconstructed epidemic among rabid are consistent with recorded human cases. This work illustrates benefits combining phylogeographic modelling approaches uncovering spatiotemporal zoonotic diseases, both providing key parameters.