DNA methylation in thyroid cancer
作者： Carles Zafon , Joan Gil , Beatriz Pérez-González , Mireia Jordà
DOI: 10.1530/ERC-19-0093
关键词: Thyroid cancer 、 Bioinformatics 、 DNA methylation 、 Potential biomarkers 、 Genomics 、 Methylation 、 Aberrant methylation 、 Cancer 、 Medicine 、 Differentially methylated regions
摘要: In recent years, cancer genomics has provided new insights into genetic alterations and signaling pathways involved in thyroid cancer. However, the picture of molecular landscape is not yet complete. DNA methylation, most widely studied epigenetic mechanism, altered Recent technological advances have allowed identification novel differentially methylated regions, methylation signatures potential biomarkers. despite progress cataloging cancer, many questions remain unanswered. The aim this review to comprehensively examine current knowledge on discuss its clinical applications. After providing a general overview dysregulation we carefully describe aberrant changes relate them patterns, global hypomethylation gene-specific alterations. We hope helps accelerate use diagnostic, prognostic therapeutic for benefit patients.
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