Basal Ganglia-Cortical Structural Connectivity in Huntington's Disease
作者： Marianne J.U. Novak , Kiran K. Seunarine , Clare R. Gibbard , Peter McColgan , Bogdan Draganski
DOI: 10.1002/HBM.22733
关键词: Trinucleotide repeat expansion 、 Basal ganglia 、 Neuroimaging 、 Pathology 、 Huntington's disease 、 Neuroscience 、 Diffusion MRI 、 Basal (phylogenetics) 、 Tractography 、 White matter 、 Psychology
摘要: Huntington's disease is an incurable neurodegenerative caused by inheritance of expanded cytosine-adenine-guanine (CAG) trinucleotide repeat within the Huntingtin gene. Extensive volume loss and altered diffusion metrics in basal ganglia, cortex white matter are seen when patients with (HD) undergo structural imaging, suggesting that changes ganglia-cortical connectivity occur. The aims this study were to characterise pat- terns high anatomical precision premanifest early manifest HD, identify associations between genetic or clin- ical markers HD. 3-Tesla tensor magnetic resonance images acquired from 14
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