Methods and diagnostic kits for the detections of HIV-2-specific antibodies employing polypeptides obtained from the simian immunodeficiency virus
作者： D. Elliot Parks , Richard A. Lerner , Erling C. J. Norrby
DOI:
关键词: Transmembrane protein 、 Glycoprotein 、 Biology 、 Simian immunodeficiency virus 、 Epitope mapping 、 Peptide sequence 、 Antibody 、 Virology 、 Molecular biology 、 Antiserum 、 Cleavage (embryo)
摘要: The simian immunodeficiency virus (SIV) is genotypically and phenotypically similar to the human type 2 (HIV-2). Both viruses display structural, biological, immunological properties. external envelope glycoprotein (EMP) transmembrane (TMP) appear be formed from cleavage of a precursor glycoprotein. Despite these similarities, number differences exist as evidenced by different migratory properties glycoproteins. present invention discloses novel SIV peptides, obtained glycoprotein, that cross-reactivity with HIV-2-specific antisera. Epitope mapping studies revealed amino acid sequence --CAFRQVC--, which corresponds residues 614-620, sine qua non for retention this cross-reactivity. These peptides are useful in diagnostic methods detection antibodies infected patients.
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