Antiobesity Effects of Melanin-Concentrating Hormone Receptor 1 (MCH-R1) Antagonists
作者： Hyae Gyeong Cheon
DOI: 10.1007/978-3-642-24716-3_18
关键词: Pharmacology 、 Melanin-concentrating hormone receptor 、 Pharmacotherapy 、 Receptor 、 Clinical value 、 Melanin-concentrating hormone 、 Energy expenditure 、 Antiobesity drugs 、 Chemistry 、 Energy homeostasis
摘要: Despite remarkable progress in the elucidation of energy balance and regulation, development new antiobesity drugs is still at stage infancy. This review describes MCH receptor system with regard to its involvement homeostasis summarizes pharmacological profiles selected small molecule MCH-R1 antagonists that are relevant for their as drugs. Although clinical value has be demonstrated, challenges unwanted side effects remain resolved, may provide an effective pharmacotherapy treatment obesity near future.
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