A Systematic Review of the Literature on the Development of Condition-Specific Preference-Based Measures of Health

摘要: Health state utility values (HSUVs) are required to calculate quality-adjusted life-years (QALYs). They frequently derived from generic preference-based measures of health. However, such may not capture health attributes relevance specific conditions. In cases, a condition-specific measure (CSPBM) be more appropriate. This systematic review aimed identify all published accounts developing CSPBMs describe and appraise the methods used. We undertook search (of Embase, MEDLINE, PsycINFO, Web Science, Cochrane Library, CINAHL, EconLit, ASSIA Management Information Consortium database) CSPBM development up July 2015. Studies were reviewed investigate used design classification systems, estimate HSUVs, validate measures. A total 86 publications identified, describing 51 CSPBMs. Around two-thirds these QALY measures; remainder designed for clinical decision making only. Classification systems 33 existing instruments; 18 developed de novo. HSUVs 34 instruments estimated using ‘composite’ approach, involving statistical modelling; ‘decomposed’ approach based on multi-attribute theory. Half papers that described estimation did report validating their Various have been at stages development. The choice between system novo or an instrument depend availability suitable measure, while decomposed composite appears determined primarily by purpose which is designed. validation remains area further