Biochemistry of the Elastic Fibers in Normal Connective Tissues and its Alterations in Diseases
作者： Jouni Uitto
DOI: 10.1111/1523-1747.EP12530093
关键词: Elastin 、 Dense connective tissue 、 Biochemistry 、 Elastic fiber 、 Fibrillogenesis 、 Connective tissue 、 Cutis laxa 、 Chemistry 、 Elastosis perforans serpiginosa 、 Fibrillin
摘要: The elastic fibers present in various connective tissues of the body are responsible for physiologic elasticity organs. These consist 2 distinct components, elastin and fiber microfibrils. Controlled synthesis balanced interaction these components essential normal fibrillogenesis. intracellular biosynthesis by tissue cells, such as smooth muscle involves assembly polypeptide chains on membrane-bound ribosomes, hydroxylation some prolyl residues to hydroxyproline, secretion polypeptides packaged Golgi vacuoles. In extracellular space molecules assemble into structures which stabilized complex covalent cross-links, desmosines. Recently, aberrations structure or metabolism have been detected a variety heritable acquired diseases affecting skin other tissues. conditions include pseudoxanthoma elasticum, cutis laxa, elastosis perforans serpiginosa, well arteriosclerosis degenerative changes vascular
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A. Sampath Narayanan, Roy C. Page, Frank Kuzan, Studies on the action of lysyl oxidase on soluble elastin. Advances in Experimental Medicine and Biology. ,vol. 79, pp. 491- 508 ,(1977) , 10.1007/978-1-4684-9093-0_42
Russell Ross, Philip J. Fialkow, Lawrence K. Altman, The Morphogenesis of Elastic Fibers Advances in Experimental Medicine and Biology. ,vol. 79, pp. 7- 17 ,(1977) , 10.1007/978-1-4684-9093-0_2
Ines Mandl, T. V. Darnule, J. A. Fierer, S. Keller, Gerard M. Turino, Elastin degradation in human and experimental emphysema. Advances in Experimental Medicine and Biology. ,vol. 79, pp. 221- 231 ,(1977) , 10.1007/978-1-4684-9093-0_19
Judith Ann Foster, Robert Mecham, Michael Imberman, Barbara Faris, Carl Franzblau, A high molecular weight species of soluble elastin-proelastin. Advances in Experimental Medicine and Biology. ,vol. 79, pp. 351- 369 ,(1977) , 10.1007/978-1-4684-9093-0_31
Darwin J. Prockop, Richard A. Berg, Kari I. Kivirikko, Jouni Uitto, Intracellular Steps in the Biosynthesis of Collagen Springer, Boston, MA. pp. 163- 273 ,(1976) , 10.1007/978-1-4757-4602-0_5
W. Hornebeck, L. Robert, Elastase-Like Enzymes in Aortas and Human Breast Carcinomas: Quantitative Variations with Age and Pathology Advances in Experimental Medicine and Biology. ,vol. 79, pp. 145- 164 ,(1977) , 10.1007/978-1-4684-9093-0_14
R. A. Anwar, G. E. Gerber, K. H. Baig, Studies on Cross-Linked Regions of Elastin Protein Crosslinking. pp. 709- 727 ,(1977) , 10.1007/978-1-4757-9113-6_39
C H J Sear, M A Kewley, C J P Jones, M E Grant, D S Jackson, The identification of glycoproteins associated with elastic-tissue microfibrils Biochemical Journal. ,vol. 170, pp. 715- 718 ,(1978) , 10.1042/BJ1700715
Judith Ann Foster, Eveline Bruenger, William R. Gray, Lawrence B. Sandberg, Isolation and amino acid sequences of tropoelastin peptides. Journal of Biological Chemistry. ,vol. 248, pp. 2876- 2879 ,(1973) , 10.1016/S0021-9258(19)44088-X
Ken Hashimoto, Richard J. DiBella, Electron Microscopic Studies of Normal and Abnormal Elastic Fibers of the Skin* Journal of Investigative Dermatology. ,vol. 48, pp. 405- 423 ,(1967) , 10.1038/JID.1967.66