Chapter Five Polyhydroxylated alkaloids that inhibit glycosidases

摘要: Publisher Summary This chapter discusses the polyhydroxylated alkaloids that inhibit glycosidases. A remarkable range of monocyclic and bicyclic are specific potent glycosidase inhibitors have been isolated from plants, microbial filtrates, insects, though latter probably sequestered them their food-plants. They include derivatives pyrrolidine, piperidme, pyrrolizidine, octahydroindolizine (indolizidine) Atortropane ring systems. An increasing number being found which also occur as glycosides. These very widespread but long remained undetected because they do not react with reagents commonly used for alkaloid detection such Dragendorff's iodoplatinate readily dissolve in solvents chloroform. can be considered analogues monosaccharides oxygen has replaced by nitrogen. glycosidases mimicking pyranosyl furanosyl moiety natural substrates, e.g., nojirimycin corresponds to glucose pyranose configuration is an inhibitor α-and β-glucosidases various sources.