The imidazoline-preferring receptor.
作者： John Lehmann , Elisabeth Koenig-Bérard , Philippe Vitou
DOI: 10.1016/0024-3205(89)90270-1
关键词: Idazoxan 、 Imidazoline receptor 、 Adrenergic alpha-Agonists 、 Pharmacology 、 Rilmenidine 、 Receptor 、 Alpha (ethology) 、 Rauwolscine 、 In vivo 、 Chemistry 、 Endocrinology 、 Internal medicine
摘要: Evidence gathered over the past ten years supports existence of subtypes alpha 2-adrenoceptors. A receptor which resembles 2-adrenoceptor, called imidazoline-preferring (IPR), is virtually insensitive to catecholamines but binds selectively imidazolines and oxazolines such as idazoxan rilmenidine. In contrast, catecholamine-preferring 2-adrenoceptor preferentially activated by including alpha-methylnorepinephrine epinephrine antagonized rauwolscine. addition different pharmacological profiles agonists antagonists, IPR 2-adrenoceptors show differences in anatomical distribution molecular properties. The evidence has been drawn primarily from vitro physiological radioligand binding studies, gradually extending into vivo even clinical studies.
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