Small-Volume 7.5% NaCl Adenosine, Lidocaine, and Mg2+ Has Multiple Benefits During Hypotensive and Blood Resuscitation in the Pig Following Severe Blood Loss

作者: Asger Granfeldt , Hayley L. Letson , Janus A. Hyldebrandt , Edward R. Wang , Pablo A. Salcedo

DOI: 10.1097/CCM.0000000000000225

关键词: LidocaineHemorrhagic shockResuscitationAnesthesiaSmall volumeAdenosineBlood lossMedicineCritical Care and Intensive Care Medicine

摘要: Objectives:Currently, there is no effective small-volume fluid for traumatic hemorrhagic shock. Our objective was to translate 7.5% NaCl adenosine, lidocaine, and Mg2+ hypotensive resuscitation from the rat pig.Design:Pigs (35–40 kg) were anesthetized bled mean arter

参考文章(36)
Frank K. Butler, John Hagmann, E. George Butler, Tactical combat casualty care in special operations. Military Medicine. ,vol. 161, pp. 3- 16 ,(1996) , 10.1093/MILMED/161.SUPPL_1.3
Robert Wayne Barbee, Penny S. Reynolds, Kevin R. Ward, Assessing shock resuscitation strategies by oxygen debt repayment. Shock. ,vol. 33, pp. 113- 122 ,(2010) , 10.1097/SHK.0B013E3181B8569D
Steven N. Vaslef, Brian J. Kaminski, Todd L. Talarico, Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine. Journal of Trauma-injury Infection and Critical Care. ,vol. 51, pp. 1153- 1160 ,(2001) , 10.1097/00005373-200112000-00022
Lorne H. Blackbourne, James Czarnik, Robert Mabry, Brian Eastridge, David Baer, Frank Butler, Basil Pruitt, Decreasing Killed in Action and Died of Wounds Rates in Combat Wounded Journal of Trauma-injury Infection and Critical Care. ,vol. 69, ,(2010) , 10.1097/TA.0B013E3181E4206F
Asger Granfeldt, Torben K. Nielsen, Christoffer Sølling, Janus A. Hyldebrandt, Jørgen Frøkiær, Lise Wogensen, Geoffrey P. Dobson, Jakob Vinten-Johansen, Else Tønnesen, Adenocaine and Mg2+ reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock Critical Care Medicine. ,vol. 40, pp. 3013- 3025 ,(2012) , 10.1097/CCM.0B013E31825FD4ED
W. R Law, P. J Carney, M. P McLane, Influence of adenosine on the stimulatory effect of isoprenaline and insulin on myocardial contractility in vivo. Cardiovascular Research. ,vol. 25, pp. 151- 157 ,(1991) , 10.1093/CVR/25.2.151
G D. Rushing, L D. Britt, Reperfusion Injury After Hemorrhage: A Collective Review Annals of Surgery. ,vol. 247, pp. 929- 937 ,(2008) , 10.1097/SLA.0B013E31816757F7
Geoffrey P. Dobson, Membrane polarity: a target for myocardial protection and reduced inflammation in adult and pediatric cardiothoracic surgery. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 140, pp. 1213- 1217 ,(2010) , 10.1016/J.JTCVS.2010.05.040