作者: Joanne Bero , Michel Frédérich , Joëlle Quetin-Leclercq
关键词: Inhibitory concentration 50 、 Traditional medicine 、 Parasitic disease 、 Ethnobotany 、 Plant composition 、 Potential source 、 Phytochemical 、 Malaria 、 Ic50 values 、 Biology
摘要: OBJECTIVES: This review covers the compounds with antiplasmodial activity isolated from plants published 2005 to end of 2008, organized according their phytochemical classes. Details are given for substances IC50 values = 11 mum. KEY FINDINGS: Malaria is a major parasitic disease in many tropical and subtropical regions responsible more than 1 million deaths each year Africa. The rapid spread resistance encourages search new active compounds. Nature particularly used traditional medicine potential source antimalarial drugs as they contain molecules great variety structures pharmacological activities. SUMMARY: A large number wide have been can play role development drugs. Ethnopharmacological approaches appear be promising way find plant metabolites that could templates designing derivatives improved properties.