Safety and efficacy of neratinib in combination with weekly paclitaxel and trastuzumab in women with metastatic HER2‑positive breast cancer: an NSABP Foundation Research Program phase I study.

作者: Rachel C Jankowitz , Jame Abraham , Antoinette R Tan , Steven A Limentani , Marni B Tierno

DOI: 10.1007/S00280-013-2262-2

关键词: Receptor tyrosine kinasePaclitaxelOncologyNeratinibErbBMonoclonalTrastuzumabInternal medicineMedicineClinical trialBreast cancer

摘要: Purpose Neratinib is an oral, small-molecule inhibitor that irreversibly binds to pan-HER (ErbB) receptor tyrosine kinases. Studies suggest dual anti-HER therapies utilized in breast cancer patients are more efficacious than single agents both the metastatic and neoadjuvant settings. In this phase I study, neratinib was combined with trastuzumab paclitaxel HER2-positive patients.

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