IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

作者: Lin Wang , Tangsheng Yi , Wang Zhang , Drew M. Pardoll , Hua Yu

DOI: 10.1158/0008-5472.CAN-10-0775

关键词: ImmunologyTumor microenvironmentCancer researchHyperplasiaBiologyInflammationCarcinogenesisInterleukin 17Innate immune systemMetastasisChemokineOncology

摘要: … Little is known about the role of IL-17 in de novo carcinogenesis. Using IL-17 knockout mice, we examined the role of IL-17 in the classic DMBA/TPA-induced skin carcinogenesis model…

参考文章(39)
Davide Agnello, Carla SR Lankford, Jay Bream, Akio Morinobu, Massimo Gadina, John J O'Shea, David M Frucht, Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. Journal of Clinical Immunology. ,vol. 23, pp. 147- 161 ,(2003) , 10.1023/A:1023381027062
Stephanie K. Bunt, Pratima Sinha, Virginia K. Clements, Jeff Leips, Suzanne Ostrand-Rosenberg, Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression Journal of Immunology. ,vol. 176, pp. 284- 290 ,(2006) , 10.4049/JIMMUNOL.176.1.284
Lelio Orci, Michael S. Pepper, Microscopy: an art? Nature Reviews Molecular Cell Biology. ,vol. 3, pp. 133- 137 ,(2002) , 10.1038/NRM726
Robert J. Moore, David M. Owens, Gordon Stamp, Caroline Arnott, Frances Burke, Nick East, Hazel Holdsworth, Lynn Turner, Barrett Rollins, Manolis Pasparakis, George Kollias, Frances Balkwill, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature Medicine. ,vol. 5, pp. 828- 831 ,(1999) , 10.1038/10552
Yoshihiro Miyahara, Kunle Odunsi, Wenhao Chen, Guangyong Peng, Junko Matsuzaki, Rong-Fu Wang, Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 15505- 15510 ,(2008) , 10.1073/PNAS.0710686105
Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao, Zhihai Qin, IFNγ Promotes Papilloma Development by Up-regulating Th17-Associated Inflammation Cancer Research. ,vol. 69, pp. 2010- 2017 ,(2009) , 10.1158/0008-5472.CAN-08-3479
John L. Langowski, Xueqing Zhang, Lingling Wu, Jeanine D. Mattson, Taiying Chen, Kathy Smith, Beth Basham, Terrill McClanahan, Robert A. Kastelein, Martin Oft, IL-23 promotes tumour incidence and growth Nature. ,vol. 442, pp. 461- 465 ,(2006) , 10.1038/NATURE04808
Shaoguang Wu, Ki-Jong Rhee, Emilia Albesiano, Shervin Rabizadeh, Xinqun Wu, Hung-Rong Yen, David L Huso, Frederick L Brancati, Elizabeth Wick, Florencia McAllister, Franck Housseau, Drew M Pardoll, Cynthia L Sears, None, A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses Nature Medicine. ,vol. 15, pp. 1016- 1022 ,(2009) , 10.1038/NM.2015
Zhi Chen, John J. O’Shea, Th17 cells: a new fate for differentiating helper T cells. Immunologic Research. ,vol. 41, pp. 87- 102 ,(2008) , 10.1007/S12026-007-8014-9
Hideki Ogura, Masaaki Murakami, Yuko Okuyama, Mineko Tsuruoka, Chika Kitabayashi, Minoru Kanamoto, Mika Nishihara, Yoichiro Iwakura, Toshio Hirano, Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction Immunity. ,vol. 29, pp. 628- 636 ,(2008) , 10.1016/J.IMMUNI.2008.07.018