Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria.
作者： Matthew S. Alkaitis , Hans C. Ackerman
DOI: 10.1021/ACSINFECDIS.6B00124
关键词: Endocrinology 、 Nitric oxide 、 Plasmodium berghei 、 Internal medicine 、 Phenylalanine 、 Nitric oxide synthase 、 Biochemistry 、 Tetrahydrobiopterin 、 Citrulline 、 Arginine 、 Phenylalanine hydroxylase 、 Biology
摘要: Tetrahydrobiopterin (BH4) is an essential cofactor for both phenylalanine hydroxylase and nitric oxide synthase. Patients with severe malaria have low urinary BH4, elevated plasma phenylalanine, impaired endothelium-dependent vasodilation, suggesting that BH4 depletion may limit metabolism synthesis. We infected C57BL/6 mice Plasmodium berghei ANKA to characterize availability investigate the effects of supplementation. P. infection lowered in plasma, erythrocytes, brain tissue but raised it aorta liver tissue. The ratio 7,8-BH2 (the major product oxidation) was decreased tissue, oxidation contributes depletion. continuous infusion sepiapterin (a precursor) citrulline (an arginine concentrations blood compartments. restoration systemic ...
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