Heat Shock Protein 60 in Obesity: Effect of Bariatric Surgery and its Relation to Inflammation and Cardiovascular Risk.
作者： Henrike Sell , Christine Poitou , Christiane Habich , Jean-Luc Bouillot , Jürgen Eckel
DOI: 10.1002/OBY.22014
关键词: Apolipoprotein B 、 Interleukin 6 、 Weight loss 、 Adipokine 、 Surgery 、 Obesity 、 Inflammation 、 Cholesterol 、 Medicine 、 Adiponectin 、 Endocrinology 、 Internal medicine
摘要: Objective Heat shock protein 60 (Hsp60) is an adipokine, and its serum concentrations are higher in patients with obesity compared to lean patients. This study aimed analyze the effect of bariatric surgery on circulating Hsp60 morbid their correlation inflammation metabolic cardiovascular risk. Methods Fifty-three females undergoing were enrolled. Serum parameters anthropometric measures obtained at baseline 3 12 months post surgery. Results During 12-month observation period, decreased significantly from 31.6 ± 4.7 ng/mL 22.3 ± 3.0 (3 months), 26.5 ± 5.5 (6 21.1 ± 3.3 (12 months). Preoperatively, correlated positively total cholesterol, low-density lipoprotein apolipoprotein B (ApoB) negatively adiponectin. At end triglycerides, ApoB, HbA1c, C-reactive (CRP). Patients highest quartile characterized by elevated CRP interleukin 6 independently BMI, glycemia, insulinemia. after surgery, ApoB/ApoA1 ratio cholesterol/high-density cholesterol ratio. Conclusions Hsp60 surgery-induced weight loss. Their inflammatory markers risk might link disease.
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