Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)
作者： Antonia P. de los Ríos , Fred van Rantwijk , Roger A. Sheldon
DOI: 10.1039/C2GC35196J
关键词: Organic chemistry 、 Acylation 、 Enzyme 、 Candida antarctica 、 Kinetic resolution 、 Anhydrous 、 Ionic liquid 、 Vinyl acetate 、 Chemistry 、 Ethanol
摘要: Herein we report the novel use of essentially anhydrous protic ionic liquids (PILs) as reaction media for performing smooth kinetic resolution 1-phenylethanol by Candida antarctica lipase B (CaLB) catalysed acylation with vinyl acetate at 40 °C. Good rates and high enantioselectivities (92–>99%) were observed suspensions both free enzyme cross-linked aggregates (CLEAs) CaLB.
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