A mechanism-based understanding of bone cancer pain.

摘要: Although bone cancer pain can be severe and is relatively common, as it frequently arises from metastases breast, prostate lung tumours, little known about the basic mechanisms that generate maintain this chronic pain. To begin to define give rise pain, we developed a mouse model using intramedullary injection containment of osteolytic sarcoma cells into femur. These tumour induced destruction well ongoing movement evoked behaviours similar found in patients with In addition, there was significant neurochemical reorganization sensory neurons innervate bearing spinal cord segments received input cancerous bone. This generated signature different observed models neuropathic or inflammatory data suggest an inflammatory, tumorigenic component Therefore defining when how these components drive may allow development more selective analgesic agents treat state.