Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection.
作者： Muhammad Aslam , Yury Ladilov
DOI: 10.3390/CELLS9091962
关键词: Cell biology 、 Viral replication 、 Endosome 、 Autophagy 、 Endocytic cycle 、 Biology 、 Endocytosis 、 Viral entry 、 Coronavirus 、 Soluble adenylyl cyclase
摘要: An outbreak of the novel coronavirus (CoV) SARS-CoV-2, causative agent COVID-19 respiratory disease, infected millions people since end 2019, led to high-level morbidity and mortality caused worldwide social economic disruption. There are currently no antiviral drugs available with proven efficacy or vaccines for its prevention. understanding underlying cellular mechanisms involved in virus replication is essential repurposing existing and/or discovery new ones. Endocytosis important mechanism entry CoVs into host cells. Endosomal maturation followed by fusion lysosomes crucial events endocytosis. Late endosomes characterized their acidic pH, which generated a proton transporter V-ATPase required via endocytic pathway. The cytoplasmic cAMP pool produced soluble adenylyl cyclase (sAC) promotes recruitment endosomes/lysosomes thus acidification. In this review, we discuss targeting sAC-specific as potential strategy impair SARS-CoV-2 cell. Furthermore, consider impact sAC inhibition on CoV-induced disease modulation autophagy apoptosis.
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