Using thermal stress to model aspects of disease states.

摘要: Exposure to acute heat or cold stress elicits numerous physiological responses aimed at maintaining body temperatures. Interestingly, many of the responses, mediated by cardiovascular and autonomic nervous systems, resemble aspects of, to, certain disease states. The purpose this Perspective is highlight some these areas in order explore how they may help us better understand pathophysiology underlying benefits using human thermal approach are that (1) no adjustments for inherent comparative differences animals needed, (2) non-medicated healthy humans with co-morbidities can be studied place complex patients, (3) more mechanistic perturbations safely employed without endangering potentially vulnerable populations. Cold used induce stable elevations blood pressure. also model conditions where increases myocardial oxygen demand not met anticipated coronary flow, as occurs older adults. Lower-body negative pressure has capacity shock, further addition improves expands because passive-heat exposure lowers systemic vascular resistance a time when central volume left-ventricular filling reduced. Heat syncope orthostatic intolerance decreases cerebral flow alters Frank–Starling mechanism resulting larger stroke given change Combined, provide vivo paradigms gain insights into pathophysiological