Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume

摘要: Hippocampal injury in the Alzheimer's disease (AD) pathological process is region-specific and magnetic resonance imaging (MRI)-based measures of localized hippocampus (HP) atrophy are known to detect changes associated with clinical AD, but it unclear whether these provide information that independent already provided by total HP volume. Therefore, this study assessed strength association between AD-related including cerebrospinal fluid (CSF) amyloid beta tau concentrations, cognitive performance, statistical models also included volume as a covariate. A computational technique termed components analysis (LoCA) was used identify 7 patterns among 390 semiautomatically delineated from baseline participants Disease Neuroimaging Initiative (ADNI). Among cognitively normal participants, multiple were significantly CSF concentration, while not. In addition, all both independently additively performance on numerous neuropsychological tests, discrimination normal, mild impairment (MCI), AD diagnostic groups. Together, results suggest regional hippocampal may be more sensitive than effects pathology burden individuals about regions whose deficits have especially profound consequences throughout course.