Neural plasticity, neuropeptides and anxiety in animals--implications for understanding and treating affective disorder following traumatic stress in humans.
作者： R Adamec , P Kent , H Anisman , T Shallow , Z Merali
DOI: 10.1016/S0149-7634(98)00032-3
关键词: Anxiety disorder 、 Bombesin 、 Endocrinology 、 Corticosterone 、 Predator 、 Internal medicine 、 Vasopressin 、 Neuroscience 、 Adrenocorticotropic hormone 、 Traumatic stress 、 Neuroplasticity 、 Psychology
摘要: Exposure of rats to cats (predator stress) lastingly increases rodent anxiety-like behavior (ALB) in the elevated plus-maze. Previous work shows that lasting changes ALB following predator stress depend on NMDA and CCKB receptors. In this paper we describe effects differing degrees exposure behavior. Effects behavioral measure. general, odor is less provocative change than unprotected a cat. addition, examine development over time. Lasting begin at 30 min 1 h after persist for least 3 weeks. We also report complex pattern neuroendocrine peptide (bombesin, CRF AVP) levels variety brain areas. Not surprisingly, plasma corticosterone ACTH. Central content hypothalamo-pituitary axis, related hypothalamic nuclei, limbic stem areas are noted. Finally, path analysis demonstrates replicable relationship between cat behavior, rat defensive degree increase one week later. It proposed may model anxiety associated with PTSD.
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