New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii
作者： Amninder Kaur , Huzefa A. Raja , Blaise A. Darveaux , Wei-Lun Chen , Steven M. Swanson
DOI: 10.1002/MRC.4254
关键词: Chemistry 、 Fermentation 、 Stereochemistry 、 Fungal isolate 、 Chemical separation 、 Microbiology 、 Human melanoma 、 Aspergillus 、 Aspergillus sydowii 、 Dimer 、 Biological activity
摘要: Prior investigations of filamentous fungi in our group have resulted the isolation several new and biologically active natural products.[1-3] Continuing these investigations, we now analyzed metabolites from a fungal isolate Aspergillus sydowii (MSX19583) that was obtained spruce litter collected 1984 Colorado, USA. The extracts solid-substrate fermentation cultures exhibited cytotoxic activity against MDA-MB-435 (human melanoma) cells were therefore pursued for further analysis. Chemical separation CH3CN/CH3OH extract afforded diketopiperazine dimer (1) addition to three known compounds including cyclo-(L-phenylalaninyl-L-tryptophanyl),[2, 4, 5] S-sydonic acid (3), S-sydonol (4) (Fig. 1).[6]
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