作者: Eckhard R. Podack , William P. Kolb , Hans J. Müller-Eberhard
DOI:
关键词: Polyacrylamide gel electrophoresis 、 Biochemistry 、 SC5b-7 complex 、 Glycoprotein 、 Biology 、 Protein subunit 、 Composition (visual arts) 、 Electrophoresis
摘要: Activation of C in C8-depleted serum results the formation a soluble complex containing C5, C6, and C7. The has an electrophoretic mobility α-globulin, s-rate 18.5S, m.w. 668,000 daltons. This was isolated upon SDS polyacrylamide gel electrophoresis it found to contain, addition C5b, C6 C7, 88,000 dalton glycoprotein. protein identified as band V C5b-9 complex. It is referred SIIIs-protein, or S-protein. Since S-protein does not bind C5b-6, concluded that incorporated during fusion C5b-6 with SC5b-7 exhibits same neoantigen SC5b-9 complex, but compared appears contain additionally qualitatively distinct neoantigen.