The SC5b-7 complex: Formation, isolation, properties, and subunit composition

作者: Eckhard R. Podack , William P. Kolb , Hans J. Müller-Eberhard

DOI:

关键词: Polyacrylamide gel electrophoresisBiochemistrySC5b-7 complexGlycoproteinBiologyProtein subunitComposition (visual arts)Electrophoresis

摘要: Activation of C in C8-depleted serum results the formation a soluble complex containing C5, C6, and C7. The has an electrophoretic mobility α-globulin, s-rate 18.5S, m.w. 668,000 daltons. This was isolated upon SDS polyacrylamide gel electrophoresis it found to contain, addition C5b, C6 C7, 88,000 dalton glycoprotein. protein identified as band V C5b-9 complex. It is referred SIIIs-protein, or S-protein. Since S-protein does not bind C5b-6, concluded that incorporated during fusion C5b-6 with SC5b-7 exhibits same neoantigen SC5b-9 complex, but compared appears contain additionally qualitatively distinct neoantigen.

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