A comparison of orally administered misoprostol with vaginally administered misoprostol for cervical ripening and labor induction

摘要: Abstract Objective: Our purpose was to compare orally administered with vaginally misoprostol for cervical ripening and labor induction. Material And Methods: Two hundred twenty subjects medical or obstetric indications induction undilated, uneffaced cervices were randomly assigned receive misoprostol. Fifty micrograms of oral 25 μg vaginal given every 4 hours. If (Bishop score ≥8 dilatation ≥3) active did not occur, repeated doses a maximum 6 24 Thereafter, oxytocin intravenously by standardized incremental infusion protocol 22 mU/min. Results: Of the 220 evaluated, 110 received Fewer who preparation (34/110, 30.9%) delivered within hours initiation induction, in comparison those (52/110, 47.3%) ( P = .01). The average interval from start delivery nearly longer treatment group (mean SD 1737.9 ± 845.7 minutes) than 1393.2 767.9) .005, log-transformed data). Orally treated patients required significantly more (orally doses: mean 3.3 1.7; 2.3 1.2) .01, relative risk 1.28, 95% confidence 1.06-1.54). Vaginal occurred 95 (86.4%) 85 (77.3%) .08, 1.12, 0.99-1.27), remainder undergoing cesarean delivery. There no difference incidence uterine contractile abnormalities (tachysystole, hypertonus, hyperstimulation), intrapartum complications, neonatal outcomes between 2 groups. Conclusions: Oral administration 50-μg appears less effective 25-μg Further investigation is needed determine whether should be used (Am J Obstet Gynecol 1999;180:1155-60.)