Maternal Fatty Acids and Their Association with Birth Outcome: A Prospective Study

作者: Akshaya Meher , Karuna Randhir , Savita Mehendale , Girija Wagh , Sadhana Joshi

DOI: 10.1371/JOURNAL.PONE.0147359

关键词: Gestational ageLow birth weightBirth weightPregnancyObstetricsFatty acidPediatricsDocosahexaenoic acidGestationGestational diabetesMedicine

摘要: Maternal nutrition, especially LCPUFA, is an important factor in determining fetal growth and development. Our earlier cross sectional study reports lower docosahexanoic acid (DHA) levels at the time of delivery mothers delivering low birth weight (LBW) babies. This was undertaken to examine role maternal omega-3 omega-6 fatty profile across gestation growth. a hospital based where women were recruited early gestation. blood collected 3 points, i.e., T1 = 16th-20th week, T2 26th-30th week T3 delivery. Cord At delivery, these divided into 2 groups: those term baby weighing >2.5kg [Normal (NBW) group] <2.5kg [LBW group]. The data on 111 T1, out which 60 delivered NBW 51 LBW term. Fatty acids analysed using gas chromatography. gestation, erythrocyte DHA positively (p<0.05) associated with weight. plasma arachidonic total higher (p<0.05 for both) group. Total while group demonstrates possible LCPUFA etiology babies right from pregnancy.

参考文章(41)
Sumithra Muthayya, Maternal nutrition & low birth weight - what is really important? Indian Journal of Medical Research. ,vol. 130, pp. 600- 608 ,(2009)
Sheila M. Innis, Metabolic programming of long-term outcomes due to fatty acid nutrition in early life. Maternal and Child Nutrition. ,vol. 7, pp. 112- 123 ,(2011) , 10.1111/J.1740-8709.2011.00318.X
Nisha S. Wadhwani, Hemlata R. Pisal, Savita S. Mehendale, Sadhana R. Joshi, A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome. Maternal and Child Nutrition. ,vol. 11, pp. 559- 573 ,(2015) , 10.1111/MCN.12062
Gabriele Saccone, Irene Saccone, Vincenzo Berghella, Omega-3 long-chain polyunsaturated fatty acids and fish oil supplementation during pregnancy: which evidence? Journal of Maternal-fetal & Neonatal Medicine. ,vol. 29, pp. 2389- 2397 ,(2015) , 10.3109/14767058.2015.1086742
Manon van Eijsden, Gerard Hornstra, Marcel F van der Wal, Tanja GM Vrijkotte, Gouke J Bonsel, Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study. The American Journal of Clinical Nutrition. ,vol. 87, pp. 887- 895 ,(2008) , 10.1093/AJCN/87.4.887
Irene Cetin, Gioia Alvino, Manuela Cardellicchio, Long chain fatty acids and dietary fats in fetal nutrition The Journal of Physiology. ,vol. 587, pp. 3441- 3451 ,(2009) , 10.1113/JPHYSIOL.2009.173062
S Muthayya, P Dwarkanath, T Thomas, S Ramprakash, R Mehra, A Mhaskar, R Mhaskar, A Thomas, S Bhat, M Vaz, A V Kurpad, The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. European Journal of Clinical Nutrition. ,vol. 63, pp. 340- 346 ,(2009) , 10.1038/SJ.EJCN.1602933
Gabriele Saccone, Vincenzo Berghella, Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth Obstetrics & Gynecology. ,vol. 125, pp. 663- 672 ,(2015) , 10.1097/AOG.0000000000000668
Anitha Kilari, Savita Mehendale, Kamini Dangat, Hemlata Pisal, Sadhana Joshi, Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. American Journal of Human Biology. ,vol. 23, pp. 319- 324 ,(2011) , 10.1002/AJHB.21129