Effect of Kaempferol Pretreatment on Myocardial Injury in Rats
作者： Anamika Vishwakarma , Thakur Uttam Singh , Soya Rungsung , Tarun Kumar , Arunvikram Kandasamy
DOI: 10.1007/S12012-018-9443-5
关键词: Lipid peroxidation 、 Blood pressure 、 Myocardial infarction 、 Kaempferol 、 Oxidative stress 、 Isoprenaline 、 Internal medicine 、 Endocrinology 、 Hemodynamics 、 Lipid profile 、 Medicine
摘要: The present study was undertaken to evaluate the effect of kaempferol in isoprenaline (ISP)-induced myocardial injury rats. ISP administered subcutaneously for two subsequent days induce injury. Assessment done by estimation hemodynamic functions, infarcted area, cardiac markers, lipid profile, oxidative stress, pro-inflammatory cytokines and histopathology heart liver. Rats pretreated with showed reduction area rate. However, no improvement observed change body weight, mean arterial, systolic diastolic blood pressure. Kaempferol significant decrease serum LDH, CK-MB, troponin-I profile. highest dose did not reduce triglyceride level. Further, antioxidant enzymes, SOD catalase, were also higher. reduced glutathione, SGOT creatinine show any improvement. MDA at pro-MMP-2 expression MMP-9 mRNA level TNF-α different kaempferol-pretreated injured rats ISP-alone group. Pretreatment mild mononuclear infiltration degenerative changes tissue section higher concentration normal cordlike arrangement hepatocytes moderate swelling (vacuolar degeneration) around central vein. Study suggests that attenuated stress ISP-induced
springer.com
sci-hub.se 参考文章(65)
M Madesh, K A Balasubramanian, Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian Journal of Biochemistry & Biophysics. ,vol. 35, pp. 184- 188 ,(1998)
Kasi Pandima Devi, Dicson Sheeja Malar, Seyed Fazel Nabavi, Antoni Sureda, Jianbo Xiao, Seyed Mohammad Nabavi, Maria Daglia, Kaempferol and inflammation: From chemistry to medicine. Pharmacological Research. ,vol. 99, pp. 1- 10 ,(2015) , 10.1016/J.PHRS.2015.05.002
Zhen Guo, Zhangping Liao, Liqing Huang, Dan Liu, Dong Yin, Ming He, Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1. European Journal of Pharmacology. ,vol. 761, pp. 245- 253 ,(2015) , 10.1016/J.EJPHAR.2015.05.056
Cheng Luo, Hui Yang, Chengyong Tang, Gaoqiong Yao, Lingxi Kong, Haixia He, Yuanda Zhou, Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats. International Immunopharmacology. ,vol. 28, pp. 744- 750 ,(2015) , 10.1016/J.INTIMP.2015.07.018
Sunanda Panda, Anand Kar, A Novel Phytochemical, Digoxigenin‐3‐O‐Rutin in the Amelioration of Isoproterenol‐Induced Myocardial Infarction in Rat: A Comparison with Digoxin Cardiovascular Therapeutics. ,vol. 30, pp. 125- 135 ,(2012) , 10.1111/J.1755-5922.2010.00242.X
Mingjie Zhou, Huanhuan Ren, Jichun Han, Wenjuan Wang, Qiusheng Zheng, Dong Wang, Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β. Oxidative Medicine and Cellular Longevity. ,vol. 2015, pp. 481405- 481405 ,(2015) , 10.1155/2015/481405
Hana Alkhalidy, William Moore, Yanling Zhang, Ryan McMillan, Aihua Wang, Mostafa Ali, Kyung-Shin Suh, Wei Zhen, Zhiyong Cheng, Zhenquan Jia, Matthew Hulver, Dongmin Liu, Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β -Cell Mass in Middle-Aged Obese Diabetic Mice. Experimental Diabetes Research. ,vol. 2015, pp. 532984- 532984 ,(2015) , 10.1155/2015/532984
Fernanda BA Paula, Cibele MCP Gouvêa, Patrícia P Alfredo, Ione Salgado, Protective action of a hexane crude extract of Pterodon emarginatus fruits against oxidative and nitrosative stress induced by acute exercise in rats BMC Complementary and Alternative Medicine. ,vol. 5, pp. 17- 17 ,(2005) , 10.1186/1472-6882-5-17
K. L. Hemalatha, P. Stanely Mainzen Prince, Antihyperlipidaemic, Antihypertrophic, and Reducing Effects of Zingerone on Experimentally Induced Myocardial Infarcted Rats Journal of Biochemical and Molecular Toxicology. ,vol. 29, pp. 182- 188 ,(2015) , 10.1002/JBT.21683
Solomon Habtemariam, Antihyperlipidemic Components of Cassia auriculata Aerial Parts: Identification Through In Vitro Studies Phytotherapy Research. ,vol. 27, pp. 152- 155 ,(2013) , 10.1002/PTR.4711