Cell Therapy Attenuates Deleterious Ventricular Remodeling and Improves Cardiac Performance After Myocardial Infarction
作者： Mohit Jain , Harout DerSimonian , Daniel A. Brenner , Soeun Ngoy , Paige Teller
DOI: 10.1161/01.CIR.103.14.1920
关键词: Ex vivo 、 Cellular cardiomyoplasty 、 In vivo 、 Internal medicine 、 Medicine 、 Infarction 、 Cardiac function curve 、 Ventricular remodeling 、 Myocardial infarction 、 Ventricle 、 Cardiology
摘要: Background—Myocardial infarction (MI) promotes deleterious remodeling of the myocardium, resulting in ventricular dilation and pump dysfunction. We examined whether supplementing infarcted myocardium with skeletal myoblasts would (1) result viable myoblast implants, (2) attenuate remodeling, (3) enhance vivo ex contractile performance. Methods Results—Experimental MI was induced by 1-hour coronary ligation followed reperfusion adult male Lewis rats. One week after MI, 106 were injected directly into infarct region. Three groups animals studied at 3 6 weeks cell therapy: noninfarcted control (control), plus sham injection (MI), (MI+cell). In cardiac function assessed maximum exercise capacity testing determined pressure-volume curves obtained from isolated, red cell–perfused, balloon–in–left ventricle (LV) hearts. MI+cell hearts had indistinguishable ...
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