Phenytoin and Congeners
作者： H. Kutt , C. L. Harden
DOI: 10.1007/978-3-642-60072-2_9
关键词: Fosphenytoin 、 Epoxide hydrolase activity 、 Phenytoin 、 Phenacemide 、 Pharmacology 、 Chemistry 、 Anticonvulsant 、 Sedation 、 Ethotoin 、 Anesthesia 、 Status epilepticus
摘要: The synthesis of 5,5-diphenylhydantoin was reported by Biltz in 1908. In 1937 Putnam and Merrutt that it elevated the threshold to electrically induced seizures cats. 1938 Merritt provided effective treatment for chronic seizures, without sedation, patients with convulsive disorders. Since then phenytoin has been one mainstays seizure therapy. 1968 Wallis et al. success status epilepticus high doses given intravenously. A water-soluble prodrug developed 1980s simplify parenteral administration (see Sect. B on fosphenytoin, below).
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