Activation of Plasma Membrane Phosphatidylinositol Turnover by Hormones

摘要: Publisher Summary This chapter discusses the increased turnover of phosphatidic acid and phosphoinositides observed after interaction hormones with plasma-membrane receptors. Certain changes in phospholipid metabolism receptor activation involve methyltransferase enzymes that convert phosphatidylethanolamine to phosphatidylcholine. The incorporation 32P other precursors into phosphatidylinositol may be a metabolic consequence an initial breakdown phosphatidylinositol. uptake phospholipids is relatively easy measure but difficult interpret. In mammalian cells, it correlates very well ability elevate intracellular Ca2+ increase phosphoinositide breakdown. Macrophages are large leukocytes can readily collected peritoneal exudate several days injection foreign substance. tripeptide formylmethionylleucylphenylalanine (fMLP) stimulates release secretory products from cytochalasin B–treated cells. Platelets have been extensively investigated because these anucleated cells obtained humans or experimental animals.