Familial Risk Ratio of Sarcoidosis in African-American Sibs and Parents

摘要: While sarcoidosis is thought to aggregate in families, little known about the risk relatives of patients. To estimate familial ratio (lambda) sibs and parents cases, authors studied 179 African-American families ascertained through an index case diagnosed at Henry Ford Hospital Detroit, Michigan. Among those enrolled between 1997 1999, 12 327 (3.7%) 11 161 (6.8%) reported a history sarcoidosis. The lambda this sample relatives, estimated by computing age, sex, race standardized incidence ratio, was 2.24 (95% confidence interval: 1.16, 3.92) for 2.82 1.41, 5.05) parents. For combined, 2.49 1.58, 3.73). Results stratified proband characteristics indicated that greater younger (lambda = 2.93, 95% 1.52, 5.12) male 3.98, 1.99, 7.12) probands. A higher also found family members born later birth order. Monte Carlo method used lambda, with similar results obtained. Overall, these indicate that, African Americans, cases have 2.5-fold increased heterogeneity disease may exist among members.