Memory loss in a nonnavigational spatial task after hippocampal inactivation in monkeys

摘要: The hippocampus has a well-documented role for spatial navigation across species, but its memory in nonnavigational tasks is uncertain. In particular, when monkeys are tested that do not require navigation, seems unaffected by lesions of the hippocampus. However, interpretation these results compromised long-term compensatory adaptation occurring days and weeks after lesions. To test hypothesis necessary memory, we selected technique avoids adaptation. We transiently disrupted hippocampal function acutely at time testing microinfusion glutamate receptor antagonist kynurenate. Animals were on self-ordered task, Hamilton Search Task. animals presented with an array eight boxes, each containing food reinforcer; one box may be opened per trial, trials separated delay. Only location boxes serves as cue to solve task. optimal strategy open once without returning previously visited locations. Transient inactivation reduced performance chance levels delay-dependent manner. contrast, no deficits seen marked nonspatial cues (color). These clearly document macaques demonstrate efficacy pharmacological this structure species. Our data bring into alignment broader framework function.