Anti β2 glycoprotein I antibodies: detection and association with thrombosis
作者： M. E. Martinuzzo , R. R. Forastiero , L. O. Carreras
DOI: 10.1111/J.1365-2141.1995.TB03317.X
关键词: Population 、 Autoantibody 、 Immunopathology 、 Endocrinology 、 Antibody 、 Beta (finance) 、 Beta 2-Glycoprotein I 、 Lupus anticoagulant 、 Internal medicine 、 Lupus erythematosus 、 Medicine
摘要: It has been demonstrated that antiphospholipid antibodies (aPL) recognize epitopes formed by anionic phospholipids and protein cofactors. beta 2 glycoprotein I (beta 2GPI) is accepted as the cofactor of anticardiolipin (aCL). In present study we explored presence clinical associations anti 2GPI IgG isotype (a 2GPI-IgG), measured ELISA. We studied sera from 169 patients with aCL and/or lupus anticoagulant (LA), including 52 systemic erythematosus 49 primary syndrome (PAPS). found 31.9% positive for a 2GPI-IgG in whole population 48.6% aCL-IgG(+) group. There was good correlation between titre aCL-IgG optical density (r = 0.69, P < 0.01). The associated (P 0.0001) LA 0.0005). However, none 23 (+) without had 2GPI-IgG. statistically significant association history venous thromboembolism (VTE) our 0.005). This observed PAPS 0.05) but not secondary (SAPS). Our confirms some aPL(+) react special experimental conditions. addition, these VTE.
sci-hub.se 参考文章(34)
P Permpikul, LV Rao, SI Rapaport, Functional and binding studies of the roles of prothrombin and beta 2- glycoprotein I in the expression of lupus anticoagulant activity Blood. ,vol. 83, pp. 2878- 2892 ,(1994) , 10.1182/BLOOD.V83.10.2878.2878
Thomas Exner, Douglas A Triplett, David Taberner, Samuel J Machin, Guidelines for testing and revised criteria for lupus anticoagulants : SSC subcommittee for the standardization of lupus anticoagulants Thrombosis and Haemostasis. ,vol. 65, pp. 320- 322 ,(1991) , 10.1055/S-0038-1648143
K Ichikawa, Y Igarashi, E Matsuura, T Sumida, T Suzuki, T Koike, T Yasuda, M Fujimoto, Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. Journal of Immunology. ,vol. 148, pp. 3885- 3891 ,(1992)
I Schousboe, beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood. ,vol. 66, pp. 1086- 1091 ,(1985) , 10.1182/BLOOD.V66.5.1086.1086
T. Exner, N. Sahman, B. Trudinger, Separation of anticardiolipin antibodies from lupus anticoagulant on a phospholipid-coated polystyrene column Biochemical and Biophysical Research Communications. ,vol. 155, pp. 1001- 1007 ,(1988) , 10.1016/S0006-291X(88)80596-5
E. Nigelharris, Silvia Pierangeli, Jorge Barquinero, Josep Ordi-Ros, Anticardiolipin antibodies and binding of anionic phospholipids and serum protein The Lancet. ,vol. 336, pp. 505- 506 ,(1990) , 10.1016/0140-6736(90)92053-K
Johannes Nimpf, Helmut Wurm, Gerhard M Kostner, β2-glycoprotein-I (apo-H) inhibits the release reaction of human platelets during ADP-induced aggregation Atherosclerosis. ,vol. 63, pp. 109- 114 ,(1987) , 10.1016/0021-9150(87)90110-9
J. ARVIEUX, B. ROUSSEL, D. PONARD, M. G. COLOMB, IgG2 subclass restriction of anti-β2 glycoprotein 1 antibodies in autoimmune patients Clinical and Experimental Immunology. ,vol. 95, pp. 310- 315 ,(2008) , 10.1111/J.1365-2249.1994.TB06529.X
LW Chamley, EJ McKay, NS Pattison, Cofactor dependent and cofactor independent anticardiolipin antibodies. Thrombosis Research. ,vol. 61, pp. 291- 299 ,(1991) , 10.1016/0049-3848(91)90106-7
Juzo Matsuda, Kengo Gohchi, Miyo Tsukamoto, Noriko Saitoh, Katsuhisa Asami, Masakatsu Hashimoto, Anticoagulant activity of an anti-β2-glycoprotein I antibody is depentent on the presence of β2-glycoprotein I American Journal of Hematology. ,vol. 44, pp. 187- 191 ,(1993) , 10.1002/AJH.2830440309