Common Themes in the Pathogenesis of Neurodegeneration
作者： Susan C. Byrne , Lewis P. Rowland , Jean Paul G. Vonsattel , Alfred T. Welzel , Dominic M. Walsh
DOI: 10.1007/978-1-84996-011-3_1
关键词: Biology 、 Neurodegeneration 、 Pathogenesis 、 Neuronal vulnerability 、 Clinical course 、 Neuroinflammation 、 Phenotype 、 Neuroscience 、 Genetic predisposition 、 Neuropathology
摘要: Neurodegenerative diseases share a number of common features with respect to clinical course, pathology, and molecular mechanisms. This chapter outlines the themes neurodegeneration, including concept selective neuronal vulnerability, genetic susceptibility, aberrant protein structures, disruption in mitochondrial function, altered axonal transport, oxidative stress, neuroinflammation. A greater understanding shared pathophysiologic processes for neurodegenerative will help develop therapeutic agents that may be beneficial range different phenotypes.
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