Metabolism of Vascular and Luminal Glutamine by Intestinal Mucosa in Vivo

摘要: Studies over the last 15 years have revealed that small intestine is a major site for metabolism of circulating glutamine in most animal species examined, including man. Because quantitative importance as vehicle transporting nitrogen among tissues, now seen to play significant role processing waste from other organs. Meanwhile, oxidation carbon provides an important source energy epithelial cells intestinal mucosa, where utilization largely localized. Glutamine has emerged quantitatively more respira¬tory fuel than glucose this tissue. Also, it apparent digestion and absorption dietary ingredients; also serves some vital metabolic functions whole organism. Neptune’s work 1965 [23], showing was vigorously oxidized C02 by incubated ileal tissue several laboratory species, appears be first reported indication may preferred substrate intestine. These studies seem attracted little attention, however, perhaps because conditions employed vitro were not easily related vivo. More direct clues arteriovenous difference measurements across nonhepatic splanchnic organs dogs [1, 7, 14], sheep [49], rats [2], man [9], uptake combined drained hepatic portal vein — stomach, large intestine, cecum, spleen, pancreas.