Measurements of Nickel in Serum and Urine as Indices of Environmental Exposure to Nickel

摘要: Nickel was measured, by atomic absorption spectrometry, in serum and urine specimens from: ( a ) healthy hospital employees (age 19-62) who had resided >1 year Sudbury, Ontario, b 18-62) Hartford, Connecticut. Subjects groups were matched according to age sex. None of the subjects occupational exposure nickel. analyzed duplicate on "blind" basis with from interspersed within each run. In population , nickel concentrations averaged 4.6 ± 1.4 µg/liter (n = 25), excretion 7.9 3.7 µg/day 19). 2.6 1.0 26), 2.5 µg/ day 20). These means all significantly different P <0.001, t test). Serum urinary not influenced or sex, nor they correlated length residence either location. municipal tap water 200 43 Sudbury (seven sites), 1.1 0.3 Hartford (five sites). Measurements are valid biological indices environmental