Concise Review: Making Stem Cells Retinal: Methods for Deriving Retinal Pigment Epithelium and Implications for Patients With Ocular Disease
作者： Lyndsay L. Leach , Dennis O. Clegg
DOI: 10.1002/STEM.2010
关键词: Macular degeneration 、 Biology 、 Disease 、 Neuroscience 、 Cellular differentiation 、 Retinal 、 Anatomy 、 Embryonic stem cell 、 Induced pluripotent stem cell 、 Retinal pigment epithelium 、 Stem cell
摘要: Stem cells provide a potentially unlimited source of for treating plethora human diseases. Regenerative therapies retinal degenerative diseases are at the forefront translation to clinic, with stem cell-derived pigment epithelium (RPE)-based treatments age-related macular degeneration (AMD) already showing promise in patients. Despite our expanding knowledge cell biology, methods deriving cells, including RPE have remained inefficient. Thus, there has been push recent years develop more directed approaches therapy. In this concise review, we summarize efforts that successful improving derivation efficiency by directing differentiation from pluripotent using developmental cues important normal specification and maturation vivo. addition, potential obstacles clinical discussed. Finally, review how induced (hiPSCs) provides vitro models studying mechanisms disease discovering new avenues treatment.
core.ac.uk
sci-hub.se 参考文章(90)
Atsushi Kuwahara, Chikafumi Ozone, Tokushige Nakano, Koichi Saito, Mototsugu Eiraku, Yoshiki Sasai, Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue Nature Communications. ,vol. 6, pp. 6286- ,(2015) , 10.1038/NCOMMS7286
Lesley Gerrard, Leigh Rodgers, Wei Cui, Differentiation of Human Embryonic Stem Cells to Neural Lineages in Adherent Culture by Blocking Bone Morphogenetic Protein Signaling Stem Cells. ,vol. 23, pp. 1234- 1241 ,(2005) , 10.1634/STEMCELLS.2005-0110
Muriel Perron, Sébastien Boy, Marcos A Amato, Andrea Viczian, Katja Koebernick, Tomas Pieler, William A Harris, A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. Development. ,vol. 130, pp. 1565- 1577 ,(2003) , 10.1242/DEV.00391
Mark H. Lee, Judith A. Arcidiacono, Anastacia M. Bilek, Jeremiah J. Wille, Caitilin A. Hamill, Keith M. Wonnacott, Martha A. Wells, Steven S. Oh, Considerations for tissue-engineered and regenerative medicine product development prior to clinical trials in the United States. Tissue Engineering Part B-reviews. ,vol. 16, pp. 41- 54 ,(2010) , 10.1089/TEN.TEB.2009.0449
Gabriel Nistor, Magdalene J. Seiler, Fengrong Yan, David Ferguson, Hans S. Keirstead, Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells Journal of Neuroscience Methods. ,vol. 190, pp. 63- 70 ,(2010) , 10.1016/J.JNEUMETH.2010.04.025
Tokushige Nakano, Satoshi Ando, Nozomu Takata, Masako Kawada, Keiko Muguruma, Kiyotoshi Sekiguchi, Koichi Saito, Shigenobu Yonemura, Mototsugu Eiraku, Yoshiki Sasai, Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs Cell Stem Cell. ,vol. 10, pp. 771- 785 ,(2012) , 10.1016/J.STEM.2012.05.009
Sabine Fuhrmann, ChangJiang Zou, Edward M. Levine, Retinal pigment epithelium development, plasticity, and tissue homeostasis. Experimental Eye Research. ,vol. 123, pp. 141- 150 ,(2014) , 10.1016/J.EXER.2013.09.003
Yohei Okada, Takuya Shimazaki, Gen Sobue, Hideyuki Okano, Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells Developmental Biology. ,vol. 275, pp. 124- 142 ,(2004) , 10.1016/J.YDBIO.2004.07.038
Tim U. Krohne, Peter D. Westenskow, Toshihide Kurihara, David F. Friedlander, Mandy Lehmann, Alison L. Dorsey, Wenlin Li, Saiyong Zhu, Andrew Schultz, Junhua Wang, Gary Siuzdak, Sheng Ding, Martin Friedlander, Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells Stem Cells Translational Medicine. ,vol. 1, pp. 96- 109 ,(2012) , 10.5966/SCTM.2011-0057
J. A. Thomson, Embryonic Stem Cell Lines Derived from Human Blastocysts Science. ,vol. 282, pp. 1145- 1147 ,(1998) , 10.1126/SCIENCE.282.5391.1145