Mountain Ultramarathon Induces Early Increases of Muscle Damage, Inflammation, and Risk for Acute Renal Injury.

摘要: Purpose: This study aimed to investigate changes in muscle damage during the course of a 217-km mountain ultramarathon (MUM). In an integrative perspective, inflammatory response and renal function were also studied. Methods: Six male ultra-runners tested four times: pre-race, at 84 km, 177 immediately after race. Blood samples analyzed for serum enzymes, acute-phase protein, cortisol, biomarkers. Results: Serum creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) increased significantly throughout race (P < 0.001, P 0.001; = 0.002, respectively), effect size (ES) denoted large magnitude damage. These enzymes from pre-race (132 ± 18, 371 66, 28 3 U/L, respectively) km (30, 1.8, 3.9-fold, respectively); further (4.6, 2.9, 6.1-fold, followed by stable phase until finish line. Regarding response, significant differences found C-reactive protein (CRP) 0.001) cortisol 0.001). CRP (0.9 0.3 mg/L) (243-fold), (257 30 mmol/L) (2.9-fold), both remained augmented Significant observed creatinine 0.03), urea 0.001), glomerular filtration rate (GFR) ES confirmed moderate Creatinine increased, GFR decreased (1.00 0.03 mg/dL, 33 6 89 5 ml/min/1.73 m2, (1.3, 3.5, 0.7-fold, plateau Conclusion: shows evidence that biomarkers presented early peak levels they last segment MUM. The had similar change addition, our data showed volunteers meet risk criteria acute kidney injury finished race, without demonstrating any clinical symptomatology.