Role of excipients in the crystallization of Albendazole

摘要: Abstract Cocrystallization of drugs in presence excipients can become an effective tool to improve physicochemical and mechanical properties which may ultimately affect its bioavailability manufacturability. Aim present investigation was understand the influence Benzoic acid (BA) on recrystallization behavior Albendazole (ABZ) using slow (conventional) evaporation technique. treated crystals showed a unique melting behavior, improved solubility (12.53 folds) dissolution rate (8.6 folds) with higher drug content (72.17%). Control batch possibility new crystalline form much properties. SEM photographs revealed bigger plate-shaped BA aspect ratio near unity flow packability crystals. Heckel parameters suggested greater plastic deformation high tensile strength negligible elastic recovery compared pure drug. FT-IR studies assumed formation hydrogen bond between excipient. Treated were stable even after six months accelerated stability study. Use directly compressible could be minimized tablet formulation case Pharmacokinetic study (3.42 times) vivo performance rats. In this study, improvement physicomechanical pharmacokinetic by cocrystallization highlighted.