Gold-Catalyzed Intermolecular Nitrene Transfer from 2H‑Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles
作者： Lei Zhu , Yinghua Yu , Zhifeng Mao , Xueliang Huang
DOI: 10.1021/OL503172H
关键词: Combinatorial chemistry 、 Pyrrole 、 Catalysis 、 Direct method 、 Carbenoid 、 Nitrene 、 Chemistry 、 Intermolecular force 、 Photochemistry
摘要: An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions gives polysubstituted good-to-excellent yields. Preliminary results indicate that nongold carbenoid pathway preferred for current pyrrole synthesis.
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